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Title: COVID-19: Current Understanding of Pathophysiology
Authors: Shrestha, Gentle Sunder
Khanal, Sushil
Sharma, Sachit
Nepal, Gaurav
Citation: ShresthaG. S., KhanalS., SharmaS., & NepalG. (2020). COVID-19: Current Understanding of Pathophysiology. Journal of Nepal Health Research Council, 18(3), 351-359.
Issue Date: 2020
Publisher: Nepal Health Research Council
Article Type: Review Article
Keywords: Coronavirus disease 2019
Severe acute respiratory syndrome coronavirus 2
Series/Report no.: Jul-Sep 2020;3028
Abstract: Abstract Coronavirus disease 2019 has emerged as a global pandemic, affecting millions of people across the globe. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the human cell after binding to the Angiotensin-Converting Enzyme 2 receptors, that are present in various organs. The involvement of the respiratory system is common and may progress to acute respiratory distress syndrome. Besides the involvement of respiratory system other systems like cardiovascular, renal, gastrointestinal and central nervous are not uncommon. In-depth understanding of the pathophysiological basis of organs and systems involvement and disease progression aids in the safe and effective management of the COVID-19 patients. It also helps to guide future well-designed clinical trials, which is the need of time. This review aims to explore the current understanding of pathophysiological basis of various organ system involvement in patients with COVID-19, that can have relevance for patient management and future research. We reviewed the articles in various databases to assemble the current evidences. Keywords: Coronavirus disease 2019; COVID-19; pathophysiology; severe acute respiratory syndrome coronavirus 2
Description: Review Article
ISSN: JNHRC Print ISSN: 1727-5482; Online ISSN: 1999-6217
Appears in Collections:Vol. 18 No. 3 (2020): Vol. 18 No. 3 Issue 48 Jul-Sep 2020

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