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Title: Antibiotic Susceptibility Pattern of Gram-negative Isolates of Lower Respiratory Tract Infection
Authors: Nepal, Rakshya
Shrestha, Basudha
Joshi, Deepak Man
Joshi, Rajesh Dhoj
Shrestha, Sanjit
Singh, Anjana
Citation: NepalR., ShresthaB., JoshiD. M., JoshiR. D., ShresthaS., & SinghA. (2018). Antibiotic Susceptibility Pattern of Gram-negative Isolates of Lower Respiratory Tract Infection. Journal of Nepal Health Research Council, 16(1), 22-26.
Issue Date: 2018
Publisher: Nepal Health Research Council
Article Type: Original Article
Keywords: Extended -spectrum ?-lactamase
Series/Report no.: Jan - Mar 2018;1117
Abstract: Abstract Background: Lower respiratory tract infection is a common cause of morbidity and mortality worldwide. A cross-sectional study was carried out with an objective to study the antibiogram of Gram-negative isolates of patients with lower respiratory tract infection visiting Kathmandu Model Hospital. Methods: A total of 274 specimens including sputum, endotracheal aspirates, suction tips were cultured as per standard microbiological technique. Antibiotic susceptibility and detection of Extended-spectrum beta- lactamases (ESBLs) were performed following Clinical Laboratory Standard Institute (CLSI 2014) guidelines. Results: Respiratory pathogens were recovered from 24.6% (n=65) cases. Klebsiella pneumoniae (40%) was the commonest isolates. The highest prevalence of multidrug-resistance (69.23%) was observed in Acinetobacter calcoaceticus baumannii complex. Extended-spectrum beta- lactamases were detected in Escherichia coli (n=4), Klebsiella pneumoniae (n=4) and Acinetobacter calcoaceticus baumannii complex (n=1). Conclusions: High prevalence of multidrug-resistance and extended- spectrum beta- lactamase producers were observed in respiratory isolates. For effective management of lower respiratory tract infections, an ultimate and detailed microbiological diagnosis and susceptibility testing is required.
Description: Original Article
ISSN: Print ISSN: 1727-5482; Online ISSN: 1999-6217
Appears in Collections:Vol. 16 No. 1 Issue 38 Jan-Mar 2018

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