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Title: C-reactive Protein Versus Neutrophil/lymphocyte Ratio in Differentiating Bacterial and Non-bacterial Pneumonia in Children
Authors: Gauchan, Eva
Adhikari, Sudhir
Citation: GauchanE., & AdhikariS. (2017). C-reactive Protein Versus Neutrophil/lymphocyte Ratio in Differentiating Bacterial and Non-bacterial Pneumonia in Children. Journal of Nepal Health Research Council, 14(3).
Issue Date: 2016
Publisher: Nepal Health Research Council
Article Type: Original Article
Keywords: Bacterial and non-bacterial pneumonia
C-reactive protein
Neutrophil to lymphocyte ratio
Series/Report no.: Sep-Dec, 2016;882
Abstract: Abstract Background: Pneumonia is a leading cause of childhood mortality in a low resource country. Simple laboratory markers can help differentiate between bacterial and non-bacterial pneumonias for appropriate management. Methods: In children aged one to 60 months with features of lower respiratory infection, C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR) were used to differentiate between bacterial and non-bacterial pneumonias. The cutoff values for detecting bacterial pneumonias were evaluated by statistical tools. Results: Bacterial pneumonia was diagnosed in 285 (43.6%) children out of 654 studied. At a cut-off value of 36 mg/L CRP was predictive of bacterial pneumonias with sensitivity and specificity of 61.8% and 91.3% respectively while the sensitivity and specificity for predicting bacterial pneumonia using NLR was 45.6% and 64% respectively with 1.28 used as a cut-off. Conclusions: Our study shows that CRP is superior to NLR in differentiating bacterial from non-bacterial pneumonias in children. Keywords: Bacterial and non-bacterial pneumonia; C-reactive protein; neutrophil to lymphocyte ratio.
Description: Original Article
ISSN: Print ISSN: 1727-5482; Online ISSN: 1999-6217
Appears in Collections:Vol. 14 No. 3 Issue 34 Sep-Dec 2016

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