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Title: Assessment of Thyroid Dysfunction During Different Trimester of Pregnancy
Authors: Prajapati, Sunita
Prajapati, Gayatri
Shrestha, Vikram
Shrestha, Sujata
Citation: PrajapatiS., PrajapatiG., ShresthaV., & ShresthaS. (2023). Assessment of Thyroid Dysfunction During Different Trimester of Pregnancy. Journal of Nepal Health Research Council, 20(4), 830-833.
Issue Date: 2022
Publisher: Government of Nepal; Nepal Health Research Council; Ramshah Path, Kathmandu, Nepal
Keywords: Hypothyroidism
Thyroid stimulating hormone
Gestational week
Series/Report no.: Oct-Dec, 2022;3712
Abstract: Abstract Background: Thyroid dysfunction is frequently seen in pregnant women and is associated with complications like miscarriage, gestational hypertension, placental abruption, pre mature delivery and fetal growth retardation and even causes impaired neuropsychological development of fetus. This study is carried out to assess the prevalence of thyroid disorder during different trimester of pregnancy. Methods: Serum samples were collected from 124 pregnant women attending Patan Academy of Health Science for ante natal visit. Free thyroxine free triiodothyronine and thyroid stimulating hormone were performed by chemiluminescent assay. Results: Out of 124 pregnant women, euthyroidism was seen in 79% (n =98) followed by subclinical hypothyroidism (10%, n=13) and primary hypothyroidism (8%, n=10). Subclinical hyperthyroidism and primary hyperthyroidism accounts for 1% (n=1), and 2% (n=2) respectively. Although, thyroid disorder was found to be more prevalent in third trimester (38.4%, n=10) but the distribution in first and second trimester (34.6%, n= 9, 27%, n= 7 respectively) were also significant. Mean fT3 and fT4 level were found to be negatively correlated with trimester (r=-0.19, p=0.027 and r=-0.29, p=0.001 respectively) whereas positive correlation of trimester was seen with TSH (r=0.08, p=0.35). Conclusions: Hypothyroidism is more common in pregnant women visiting tertiary care hospital. Different complication can be minimized if diagnosis is done early. Keywords: Hypothyroidism; pregnant; thyroid stimulating hormone; trimester, gestational week
Description: Original Article
ISSN: Print ISSN: 1727-5482; Online ISSN: 1999-6217
Appears in Collections:Vol 20 No 04 Issue 57 Oct-Dec, 2022

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