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dc.contributor.authorGyawali, Pratiksha-
dc.contributor.authorBhatt, Rajendra Dev-
dc.contributor.authorKarmacharya, Robin Man-
dc.contributor.authorPant, Vivek-
dc.contributor.authorKhadka, Ayesha-
dc.identifier.citationGyawaliP., BhattR. D., KarmacharyaR. M., PantV., & KhadkaA. (2023). High Burden of Vitamin B12 Deficiency among Adults and Elderly. Journal of Nepal Health Research Council, 20(3), 702-707.
dc.identifier.issnPrint ISSN: 1727-5482; Online ISSN: 1999-6217-
dc.descriptionOriginal Articleen_US
dc.description.abstractAbstract Background: Deficiency of vitamin-B12 is widespread. Adults and the elderly are particularly susceptible to vitamin-B12 deficiency. This study investigated the burden of vitamin-B12 deficiency and insufficiency among adults and the elderly attending a tertiary care hospital in Nepal. Methods: This is a retrospective chart review conducted at Dhulikhel hospital. We reviewed records of 1615 patients investigating Vitamin-B12 level (pmol/L) at the clinical biochemistry laboratory from laboratory management database MIDAS between June 2020 and December 2021. Vitamin-B12 level was measured using enzyme immunoassay in Abbott Architect i1000SR analyzer. The categorical variables are presented as frequency and percentage; and numerical variables as means and standard deviations, or median and Interquartile range. Pearson Chi-square test was used to determine association between categorical variables. Mann Whitney test and Kruskal Wallis H test were used to compare Vitamin-B12 level by categories. Results: There were 1454 participants of which 33.5% of the patients were deficient, 27.9% were borderline deficient, while 38.7% had adequate vitamin B12 levels. Young adults(170.4 pmol/L) had a lower median vitamin B12 level than middle-aged adults (183.7pmol/L) and the elderly population (247.9pmol/L) (P<0.001). Compared to females (186.7 pmol/L), males(171.9 pmol/L) had lower vitamin B12 level (P <0.05). Conclusions: The study revealed that a significant proportion of young adults, middle aged adults and elderly population visiting a tertiary care hospital of Nepal are having vitamin B12 deficiency and borderline deficiency of public health concern. Keywords: Adults; deficiency; elderly, vitamin B12.en_US
dc.publisherNepal Health Research Councilen_US
dc.relation.ispartofseriesJuly-Sep, 2022;4407-
dc.subjectvitamin B12en_US
dc.titleHigh Burden of Vitamin B12 Deficiency among Adults and Elderlyen_US
dc.typeJournal Articleen_US
Appears in Collections:Vol 20 No 3 Issue 56 july-Sep, 2022

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