Issue 55 April-June, 2022 https://hdl.handle.net/20.500.14356/877 2026-04-13T10:34:29Z 2026-04-13T10:34:29Z Paudel, Sushil Parajuli, Niraj Shrestha, Shraddha Hirachan, Shashi https://hdl.handle.net/20.500.14356/964 2023-05-31T07:17:31Z 2022-01-01T00:00:00Z

Title: Translation, Cultural Adaptation and Validation of Cardiff Acne Disability Index in Nepali Language Authors: Paudel, Sushil; Parajuli, Niraj; Shrestha, Shraddha; Hirachan, Shashi Abstract: Abstract Background: Acne causes significant impairment in the quality of life of patients, but clinicians in Nepal lack a simple validated tool to measure the psychological side of acne. We planned to translate and validate Cardiff Acne Disability Index, a five item questionnaire into Nepali language to address this need. Methods: A linguistic translation with semantic equivalence to the original English language Cardiff Acne Disability Index was achieved through standard forward and backward translation into Nepali language. All eligible patients were requested to fill the Nepali translated version of both Cardiff Acne Disability Index and Dermatology Life Quality Index questionnaires. Reliability and validity of the newly translated questionnaire were established, based on statistical analyses of factor structure, item correlations and concurrent correlations. Results: This validity study included 94 patients with male: female ratio of 1:3.27 and mean age 21.29 (±3.92) years. Reliability analysis revealed a Cronbach’s alpha of .72 and mean inter item correlation coefficient of .337. A single factor was extracted on Principal Component Analysis explaining 48.40% of variance. A strong correlation of Cardiff Acne Disability Index scores to the Dermatology Life quality Index score (rs>.7) indicated good concurrent validity. Conclusions: The newly translated Nepali Cardiff Acne Disability Index is a valid tool to measure the impact of acne in Nepalese patients. This short and simple assessment tool will help clinicians understand the patient’s perspective of her acne. Keywords: Acne; cardiff acne disability index; quality of life; validity. Description: Original Article

2022-01-01T00:00:00Z Basnet, Ajaya Chand, Arun Bahadur Pokhrel, Nayanum Acharya, Sadikchya Gurung, Parbati Khanal, Laxmi Kant Shrestha, Kundu Shrestha, Lok Bahadur Raghubanshi, Bijendra Raj https://hdl.handle.net/20.500.14356/963 2023-05-31T07:17:31Z 2022-01-01T00:00:00Z

Title: Antimicrobial Susceptibility Pattern in Opportunistic Pathogens Isolated from Immunocompromised Patients Authors: Basnet, Ajaya; Chand, Arun Bahadur; Pokhrel, Nayanum; Acharya, Sadikchya; Gurung, Parbati; Khanal, Laxmi Kant; Shrestha, Kundu; Shrestha, Lok Bahadur; Raghubanshi, Bijendra Raj Abstract: Abstract Background: Brought with the advancements in transplantation science and the development of immunosuppressive agents, immunocompromised patients characterized with defective immunity have increased throughout the world with increased risk for opportunistic infections. This study provides an overview of the antimicrobial susceptibility pattern among opportunistic pathogens isolated from immunocompromised patients. Methods: Clinical and laboratory records of immunocompromised patients [patients with chronic kidney disease neutropenia, diabetes, rheumatic heart disease acquired immune deficiency syndrome hepatitis B, hepatitis C, who were subjected to microbiological culture analysis in the Department of Clinical Microbiology, KIST Medical College and Teaching Hospital, for 2 years (January 2019 and December 2020) were analyzed. Results: Out of 8,402 immunocompromised patients, 954 (11.4%) patients were subjected to microbiological culture analysis. Among 954 patients, 253 (26.5%) patients [median(interquartile range) age: 52(31-67) years; male 138 (54.5%)] were infected. A total of 295 pathogens were isolated from 1,331 cultured samples. Infections due to Escherichia coli (n=71, 24.1%), Klebsiella spp. (n=55, 18.6%), Acinetobacter calcoaceticus-baumannii complex (n=35, 11.9%), Candida albicans (n=30, 10.2%), and Staphylococcus aureus (n=28, 9.5%) were frequently observed. Among the bacterial isolates (n=239), 81.6% (n=195) of bacteria were β-lactamase producers, 51.0% (n=122) were multi-drug resistant, 9.2% (n=195) were extensively-drug resistant, 0.8% (n=195) were pan-drug resistant, and 35.7% (n=10) of S. aureus were methicillin-resistant Staphylococcus aureus. Conclusions: The majority of infection in immunocompromised patients is caused by Gram-negative bacteria, and is often associated with a higher number of β-lactamase producers and multi-drug resistant organisms. Prescriptions of antibiotics on the grounds of antimicrobial stewardship might help to reduce the burden of antimicrobial resistance. Keywords: Antimicrobial resistance; immunocompromised host; opportunistic infections.

2022-01-01T00:00:00Z Finsterer, Josef https://hdl.handle.net/20.500.14356/924 2023-05-31T07:17:29Z 2022-01-01T00:00:00Z

Title: Before Attributing Polyradiculitis to an Anti-SARS-CoV-2 Vaccine, Differential Etiologies need to be Ruled Out Authors: Finsterer, Josef Abstract: NA Description: Letters to the Editor

2022-01-01T00:00:00Z Paudyal, Sanjaya Chaudhary, Prakash Joshi, Mukund Raj https://hdl.handle.net/20.500.14356/923 2023-05-31T07:17:29Z 2022-01-01T00:00:00Z

Title: Synchronous Primary Adenocarcinoma of Distal Common Bile Duct and Gall bladder Authors: Paudyal, Sanjaya; Chaudhary, Prakash; Joshi, Mukund Raj Abstract: Abstract Synchronous primary cancer of the gall bladder and distal common bile duct is rare. There are only few case reports and case series available of these synchronous cancers. Management of this tumor is individualized in these case reports and series based upon the presentation. We present a case of a patient who had multifocal adenocarcinoma involving distal common bile duct and gall bladder. Keywords: Distal common bile duct cancer; gall bladder cancer; synchronous primary Description: Case Report

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