https://hdl.handle.net/20.500.14356/1798 2026-04-20T16:24:23Z https://hdl.handle.net/20.500.14356/1882 Title: A Rare Form of Cushing’s Syndrome in a 10 Year Old Child Authors: Regmi, N; Nahian, S AI Abstract: Abstract Adrenocortical carcinoma as a cause of Cushing’s syndrome in a child is a rare occurrence. Functioning adrenal carcinomas are detected usually when they are small while non-functioning tumors are incidentally detected when they grow to a large size. Here we report a case of Cushing’s syndrome due to large functioning adrenal carcinoma(>12 cm in size) in a 10 year old female child who presented with clinical features of Cushing’s syndrome along with virilisation. A combination of biochemical laboratory reports along with radiological investigations followed by histopathology helped us to arrive at a proper diagnosis. The tumor was ressected and the patient showed clinical signs of improvement. However, the surgical margin showed invasion by the tumor making a likely possibility of recurrence in the near future. Keywords: Adrenocortical carcinoma; Computed Tomography Scan of abdomen; Cushing’s syndrome; recurrent disease; total resection. Description: Case Report 2013-01-01T00:00:00Z https://hdl.handle.net/20.500.14356/1881 Title: Mucopolysaccharidosis Type II with Inguinal Hernia Authors: Rayamajhi, A; Pokharel, P J; Chapagain, R; Rayamajhi, A K Abstract: Abstract Mucopolysaccharidosis Type II (Hunter syndrome) is a rare X-linked recessive storage disorder caused by deficiency of lysosomal enzyme iduronate-2-sulfatase, causing excess accumulation of glycosaminoglycans in the lysosomes resulting in cellular damage, organ failure and death. Severe subtype develops characteristic clinical features and cognitive impairment early and die in second decade of life. In a resource poor setting, we report a case of Hunter syndrome, severe subtype, based on global development delay, coarse facies, short stature, hepatosplenomegaly and dysostosis multiplex on X-ray with unusual large congenital inguinal hernia. The diagnosis was important because of risk of recurrence of hernia after repair. Keywords: glycosaminoglycans; Hunter syndrome; iduronate-2-sulfatase deficiency; inguinal hernia; mucopolysaccharidosis. Description: Case Report 2013-01-01T00:00:00Z https://hdl.handle.net/20.500.14356/1880 Title: Review on Panton Valentine Leukocidin Toxin Carriage among Staphylococcus aureus Authors: Shrestha, B Abstract: Abstract Panton Valentine leukocidin is a toxin making pores in the polymorphonuclear cells whichis a virulence factor of some strains of Staphylococcus aureus. Initially it was produced by methicillin susceptible Staphylococcus aureusonly. Later with the acquisition of mecAgene has lead it to be PVL positive methicillin resistant Staphylococcus aureus. Since MRSA are resistant to many antibiotics and further they produce a toxin the infections by PVL positive MRSA has become a challenge. PVL positive MRSA a virulent strain of drug resistant superbug MRSA that has spread around the world, has claimed many lives in UK, Europe, USA and Australia. Some strains of superbug attack the healthy young people and kill within 24 hrs.PVL positive Staphylococcus aureushas been reported to be associated with skin and soft tissue infections however they also cause invasive infections and necrotizing pneumonia. These microorganisms known to be community associated have spread to hospitals. Hospital acquired infection by such microorganisms lead to an increase in mortality hence should be controlled before they become prevalent in hospitals. Keywords: community acquired; hospital acquired ;MRSA;MSSA; PVL. Description: Short Communication 2013-01-01T00:00:00Z https://hdl.handle.net/20.500.14356/1879 Title: Oral and Dental Complications of Head and Neck Radiotherapy and their Management Authors: Mod, D; Mod, H; Jha, A Abstract: Abstract Cancer patients who are diagnosed early and or receive effective anti tumour therapy can expect to live for many years after treatment and therefore preservation of normal tissue function is crucial to ensure long term quality of life. Oral complications affect hundred per cent of patients who receive radiotherapy to fields involving the oral cavity and combined modality treatment with chemotherapy may compound these effects. Oral cavity is highly susceptible to side effects as radiotherapy targets cells that divide rapidly and the cells of the mucosal lining of the mouth are rapidly dividing cells and they are thus injured. All patients who are to receive radiotherapy to the head and neck region should be sent for a dental consultation prior to the initiation of their treatment in order to decrease the acute and chronic post treatment sequelae. Keywords: Dental management; head and neck cancers; radiotherapy. Description: Short Communication 2013-01-01T00:00:00Z