Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14356/1108
Title: Prevalence and Pregnancy Outcomes of Intrahepatic Cholestasis of Pregnancy
Authors: Sitaula, Deekshanta
Timalsina, Santosh
Sharma, Basant
Pokharel, Bandana
Thapa, Rohit
Citation: SitaulaD., TimalsinaS., SharmaB., PokharelB., & ThapaR. (2021). Prevalence and Pregnancy Outcomes of Intrahepatic Cholestasis of Pregnancy. Journal of Nepal Health Research Council, 19(2), 321-326. https://doi.org/10.33314/jnhrc.v19i2.3455
Issue Date: 2021
Publisher: Nepal Health Research Council
Article Type: Original Article
Keywords: Intrahepatic cholestasis of pregnancy
liver function tests
neonatal outcome
obstetric cholestasis
Series/Report no.: Apr-June, 2021;3455
Abstract: Abstract Background: Intrahepatic cholestasis of pregnancy is a common pregnancy-specific liver disease associated with increased risk of adverse fetal and maternal outcomes. We sought to determine its prevalence, risk factors and feto-maternal outcomes. Methods: A retrospective review of data of 164 pregnant women diagnosed with intrahepatic cholestasis of pregnancy at Chitwan Medical College, Nepal from August 2018 to September 2020 was done. Socio-demographic data, clinic-laboratory profile and feto-maternal outcomes were obtained from clinical audit books and electronic records. A multivariate logistic regression analysis was used to evaluate the predictors of adverse neonatal outcome. Results: The prevalence of intrahepatic cholestasis of pregnancy was 2.5% (164 out of 6539 deliveries). The mean age was 27.5 ± 4.4 years and 51.2% were multigravida. The preterm delivery rate was 15.2% and Caesarean delivery rate was 69.5%. 22% of the neonates needed intensive care admission out of which Respiratory Distress Syndrome or Transient Tachypnea of Newborn was seen in half of them. There were 2 cases of Intrauterine Fetal Death. In multivariate analysis, delivery <34 weeks of gestation was only found to be a significant independent predictor of adverse neonatal outcome Conclusion: The prevalence of intrahepatic cholestasis of pregnancy among pregnant women is significant in our setting which is associated with adverse fetal outcome. Early diagnosis and timely intervention is necessary in order to reduce associated perinatal morbidity. Keywords: Intrahepatic cholestasis of pregnancy; liver function tests; neonatal outcome; obstetric cholestasis
Description: Original Article
URI: http://103.69.126.140:8080/handle/20.500.14356/1108
ISSN: Print ISSN: 1727-5482; Online ISSN: 1999-6217
Appears in Collections:Vol. 19 No. 2 (2021): Vol 19 No 2 Issue 51 Apr-Jun 2021

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