Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14356/1196
Title: Distribution of Hemoglobinopathy in Nepalese Population
Authors: Shrestha, Rekha Manandhar
Pandit, Roshana
Yadav, Udaya Kumar
Das, Rameshwar
Yadav, Binod Kumar
Upreti, Harish Chandra
Citation: ShresthaR. M., PanditR., YadavU. K., DasR., YadavB. K., & UpretiH. C. (2020). Distribution of Hemoglobinopathy in Nepalese Population. Journal of Nepal Health Research Council, 18(1), 52-58. https://doi.org/10.33314/jnhrc.v18i1.2303
Issue Date: 2020
Publisher: Nepal Health Research Council
Article Type: Original Article
Keywords: Hemoglobinopathy
Nepal
Sickle cell
Thalassemia
Series/Report no.: Jan-Mar 2020;2303
Abstract: Abstract Background: Sickle cell and thalassemia are the inherited disorders of globin chain synthesis, and are the most common monogenic disease worldwide. This study aims to find the distribution of hemoglobinopathies (sickle cell and thalassemia) cases in Nepal using laboratory based data. Methods: A retrospective study was carried out at five different sites of Nepal Government that uses capillary electrophoresis for screening of hemoglobin disorders from January 2019 to March 2019. All the cases diagnosed positive for hemoglobinopathy till December 2018 were collected from laboratory record at each sites, and analyzed using Statistical Package for Social Sciences (SPSS version 20.0). Results: Out of total 4018 patients tested during the period in all five different sites, 1470 were diagnosed positive for hemoglobinopathy. Sickling disorder was the most predominant hemoglobinopathy followed by ?-thalassemia. Province 5, province 6 and province 7 were mostly affected by sickling disorder while the other provinces by ?-thalassemia. Conclusions: Sickle cell is the commonest cause of hemoglobinopathy followed by B thallesmias in Nepalese population. Sickle cell is more concentrated towards western part of Nepal and especially in Tharu ethnic population. In contrast, the distribution of ?-thalassemia is found throughout the country and among all ethnic groups of population. Keywords: Hemoglobinopathy; Nepal; sickle cell; thalassemia
Description: Original Article
URI: http://103.69.126.140:8080/handle/20.500.14356/1196
ISSN: JNHRC Print ISSN: 1727-5482; Online ISSN: 1999-6217
Appears in Collections:Vol. 18 No. 1 (2020): Vol. 18 No. 1 Issue 46 Jan-Mar 2020

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