Glycemic Status in Organophosphorus Poisoning

Abstract

Abstract Background: Organophosphorus (OP) poisoning, in addition to its cholinergic manifestations shows metabolicderangements leading to hyperglycemia. Apart from inhibiting acetylcholinesterase it also induces oxidative stressto exhibit this manifestation. The present study aims to assess the glycemic status of OP poisoned patients and its association with various factors in OP poisoning like oxidative stress and dose of atropine.

Methods:Â This is a prospective study which recruited 102 patients above 18 years of age with history of OP poisoning.They were categorized into 3 grades-mild, moderate and severe based on the Peradeniya Organophosphorus Poisining Scale. The routine biochemical parameters along with serum malondialdehyde (MDA) and cholinesterase were estimated in the study group.

Results: Hyperglycemia and glycosuria were observed, with majority cases of hyperglycemia (57%) noticed in thesevere group. There was a rise in the random plasma glucose (RPG), serum malondialdehyde (MDA), total dose ofatropine across the groups along with a fall in the serum cholinesterase with increase in severity of poisoning. The fallin plasma glucose at the time of discharge was significant in all three groups when compared to the admission randomplasma glucose(RPG) level. This transient hyperglycemia exhibited a significant positive association with serum MDAand dose of atropine administered during treatment (p<0.05).

Conclusions: Glycemic status in OP poisoning may play a role in identifying the severity of poisoning at the time ofadmission.