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Title: Antimicrobial Susceptibility Pattern in Opportunistic Pathogens Isolated from Immunocompromised Patients
Authors: Basnet, Ajaya
Chand, Arun Bahadur
Pokhrel, Nayanum
Acharya, Sadikchya
Gurung, Parbati
Khanal, Laxmi Kant
Shrestha, Kundu
Shrestha, Lok Bahadur
Raghubanshi, Bijendra Raj
Citation: BasnetA., ChandA. B., PokhrelN., AcharyaS., GurungP., KhanalL. K., ShresthaK., ShresthaL. B., & RaghubanshiB. R. (2023). Antimicrobial Susceptibility Pattern in Opportunistic Pathogens Isolated from Immunocompromised Patients. Journal of Nepal Health Research Council, 20(3), 664-671.
Issue Date: 2022
Publisher: Nepal Health Research Council
Keywords: Antimicrobial resistance
Immunocompromised host
Opportunistic infections
Series/Report no.: July-Sep, 2022;4047
Abstract: Abstract Background: Brought with the advancements in transplantation science and the development of immunosuppressive agents, immunocompromised patients characterized with defective immunity have increased throughout the world with increased risk for opportunistic infections. This study provides an overview of the antimicrobial susceptibility pattern among opportunistic pathogens isolated from immunocompromised patients. Methods: Clinical and laboratory records of immunocompromised patients [patients with chronic kidney disease neutropenia, diabetes, rheumatic heart disease acquired immune deficiency syndrome hepatitis B, hepatitis C, who were subjected to microbiological culture analysis in the Department of Clinical Microbiology, KIST Medical College and Teaching Hospital, for 2 years (January 2019 and December 2020) were analyzed. Results: Out of 8,402 immunocompromised patients, 954 (11.4%) patients were subjected to microbiological culture analysis. Among 954 patients, 253 (26.5%) patients [median(interquartile range) age: 52(31-67) years; male 138 (54.5%)] were infected. A total of 295 pathogens were isolated from 1,331 cultured samples. Infections due to Escherichia coli (n=71, 24.1%), Klebsiella spp. (n=55, 18.6%), Acinetobacter calcoaceticus-baumannii complex (n=35, 11.9%), Candida albicans (n=30, 10.2%), and Staphylococcus aureus (n=28, 9.5%) were frequently observed. Among the bacterial isolates (n=239), 81.6% (n=195) of bacteria were β-lactamase producers, 51.0% (n=122) were multi-drug resistant, 9.2% (n=195) were extensively-drug resistant, 0.8% (n=195) were pan-drug resistant, and 35.7% (n=10) of S. aureus were methicillin-resistant Staphylococcus aureus. Conclusions: The majority of infection in immunocompromised patients is caused by Gram-negative bacteria, and is often associated with a higher number of β-lactamase producers and multi-drug resistant organisms. Prescriptions of antibiotics on the grounds of antimicrobial stewardship might help to reduce the burden of antimicrobial resistance. Keywords: Antimicrobial resistance; immunocompromised host; opportunistic infections.
ISSN: 1999-6217
Appears in Collections:Vol 20 No 02 Issue 55 April-June, 2022

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